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N1 - Funding Information:We would like to thank all the members of the J. Kipnis laboratory for their valuable comments during multiple discussions of this work. We thank Anita Impagliazzo for the artwork (graphical abstract). This work was supported by grants from the National Institutes of Health (AG034113 and NS081026 to J. Kipnis; T32-AI007496 to A.J. Filiano; and 5F30AI109984 to J.C. Cronk) and the Hartwell Foundation (to A.J. Filiano). The authors declare no competing financial interests. Author contributions: J.C. Cronk designed and performed experiments and wrote the manuscript. A.J. Filiano designed and performed experiments and wrote the manuscript. A. Louveau helped with experimental design and performed experiments. I. Marin designed and performed experiments related to intestinal macrophages. R. Marsh assisted with experiments involving flow cytometry and image analysis. E. Ji assisted with experiments involving flow cytometry and image analysis. D.H. Goldman performed experiments related to live imaging. I. Smirnov performed most surgeries. N. Geraci designed and performed bioinformatic analysis. S. Acton designed analysis related to live imaging. C.C. Overall designed, performed, and oversaw bioinformatic analysis and wrote the manuscript. J. Kipnis oversaw the project, designed experiments, and wrote the manuscriptFunding Information:This work was supported by grants from the National Institutes of Health (AG034113 and NS081026 to J. Kipnis; T32-AI007496 to A.J. Filiano; and 5F30AI109984 to J.C. Cronk) and the Hartwell Foundation (to A.J. Filiano). The authors declare no competing financial interests.Publisher Copyright: 2018 Cronk et al. 59ce067264
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